Eric Dane, best known for portraying Dr. Mark Sloan on the hit medical drama Grey’s Anatomy, has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS).

US media outlets reported Thursday that the actor passed away in the afternoon. His family confirmed the news in a statement shared with CBS and other major networks.

“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS,” the family said. The condition, also known as Lou Gehrig’s disease, is a progressive neurological disorder that affects nerve cells in the brain and spinal cord, leading to muscle weakness and loss of motor function.

Eric Dane’s ALS Diagnosis and Public Battle

Dane revealed in 2025 that he had been diagnosed with ALS. His announcement sparked an outpouring of support from fans, co-stars and the wider entertainment industry. Throughout his illness, he was praised for his strength and openness about living with the disease.

A Career Defined by Iconic Roles

Born in San Francisco, Dane made his television debut in 1991 with an appearance on Saved by the Bell. However, his breakout moment came in 2006 when he joined Grey’s Anatomy as the charismatic plastic surgeon Dr. Mark “McSteamy” Sloan.

He appeared in 139 episodes of the long-running ABC series through 2021, becoming one of the show’s most memorable characters. His portrayal helped solidify the drama’s global popularity.

Beyond Grey’s Anatomy, Dane also starred in HBO’s critically acclaimed series Euphoria, demonstrating his range in more complex roles.

Eric Dane’s legacy lives on through his unforgettable performances and his brave fight against ALS.